• T Wrona

Genetic Potentiation

Your genetic potential, potentiated.

How does the body know what items to favor, and then proliferate, and which not to? How does the body maintain awareness of the state of itself?

In a couple words: the immune system. The immune system does that, monitoring inputs and outputs.

When it comes to checking up on the state of things, whether those things are cells, neurons, antibodies, mitochondria, native or foreign, the immune system and the nervous system work together to keep the body in check.

Sunlight helps, too. The sun can optimize cell growth and development because it tunes mitochondria and their inner membranes to the optimal oscillation. It energizes them so that they can efficiently turn electrons into usable energy. They’re an energy converter, and much more than that, too. The source of all this negentropic energy is the sun.

It’s been known by scientists and physicians for many decades now that some cells begin life

in an undifferentiated state.

It’s been known for much less time that mitochondria has its own set of DNA, independent of nuclear genetics. It’s called mtDNA, and it’s what oversees the entire process of cell differentiation. It determines the vitality of a developing cell.

mtDNA determines the this somewhat pre-determined process. It’s a balancing act. Usually, though, mitochondria ‘win’; they have more of a say.

Epigenetics trump genetics. This is because genetic expression is determined by the regenerative abilities of your mitochondria.

Even mitochondria have eCB receptors. This was discovered only recently, but has only further implicated cannabinoids in having a role in just about everything.

Cannabinoids calm down the brain via retrograde signalling, increased inhibitory neurotransmitter activity, and also through downregulated respiration by slowing down mitochondrial process. Might it be that this slowdown allows for structure to be enhanced, for repairs to be made? It is only transient, after all.

mtDNA CB1 activation =

less oxygen uptake by mitochondria=

less oxidative stress =

repair cycles.

What does an endocannabinoid do to its mitochondrial receptor ~to the mitochondria itself~ when in this restful state? I would suggest that it does something important. If mitochondrial biogenesis is slowed down, this should give the body more time to determine how to best differentiate things. How to best structure itself. And, while this is being figured out, oxidants are dealt with and scavenged for.

Think about what happens when we slow down. You know, like physically — whether it’s sleeping in, taking some time off work, going on vacation, or practicing stillness for a while.

Such a state of being frees us from doing. Which is good, because doing often causes us to lose context, energy, and efficiency. Slowing down gives time for insight, and insight leads us to move forward in a more effective way. I believe the same macroscopic concept can apply to the effects of eCB’s on mitochondrial function and energy production.

The ECS ~ if its language was represented in expressed words and not in impulses and chemical signals ~ would probably say to us,

“Slow down. Take some time to reset, and become optimal before getting back up to speed. Make structural changes + streamline processes now, before things get fast again. And then let’s go for it!”

Or something like that. That’s my conceptualization, at least.

A process with positive feedback loops will get potentiated; that is, strengthened over time.

Before end results lead to anything that important, initial process needs to be ideal.

Once the transient effects of eCB or pCB influx have worn off, cellular respiration resumes as normal, just with greater efficiency. The shifts that happen during CB exposure trigger neuroplastic developments that remain over time. And these beneficial changes only get more and more potentiated!

Long term potentiation, mitochondrial biogenesis, and Endocannabinoid signalling all work through retrograde signalling.

These similarities tell us something: the body is smart enough to recognize the need for built in feedback mechanisms.

For more info, check out these studies + dig into the details!

Siegmund et al, 2007. Laura Tedesco et al, 2010. Etienne Hebert-Chatelain, 2016.

Written [in a semi-mystical fashion] by Thomas Wrona, Copywriter, circa 2018.