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Omegas and Endocannabinoids: The Hidden Link

There’s more than one way to boost your endocannabinoid system.


While I’ve said that before, the concept is probably important enough to warrant a few more mentions…and in this case, there’s something you should know:


Endocannabinoids aren’t made from CBD, or from any other exogenous cannabinoid. They’re made from essential fatty acids.


CBD may help boost endocannabinoids, for sure, which is why so many people experience amazing results from it.


But it’s not the primary rate-limiting factor involved in how one thinks, moves, or feels. That would be the essential fatty acids, notably the omega 3’s and their relation to omega 6.


It’s true — just take a look!


Thus, there is considerable overlap in effects of n-3 PUFA and the endocannabinoid system; however, these different classes of lipid mediators have traditionally been viewed and researched separately. This view is now being challenged as there are a growing number of independent lines of evidence suggesting a complex interplay between them. For example, analogous series of ethanolamide endocannabinoid-like molecules derived from DHA and EPA have been identified, although their biological roles have yet to be established [11, 12].


Furthermore, in recent elegant work long-term dietary n-3 PUFA deficiency in mice abolished endocannabinoid-mediated neuronal functions across a range of different brain regions, showing for the first time how the endocannabinoid system can be regulated by manipulation of the dietary n-6:n-3 PUFA ratio [1315]. This is a cause for concern as the Western diet typically has an n-6:n-3 PUFA ratio of around 15:1, whereas the ideal ratio is thought to be closer to 4:1 [16].


This unbalanced intake is reflected in low to very low tissue levels of DHA and EPA [17], and may also be involved in the etiology of many diseases, such as cardiovascular disease, cancer, inflammatory and autoimmune diseases [16].


It makes little sense supplementing with CBD while simultaneously eating a high omega 6:3 diet. That’d be like throwing water on fire (the fire of inflammation, that is) while also trying to quell it!


The verdict?


Take CBD — but take it alongside a diet that also helps your endocannabinoid system function at its best.





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@ 2o20  By Thomas WronA